Irf4 b cell
WebSep 29, 2024 · In vitro Stimulation of Human B Cells Generated Populations With Distinct IRF4 and Pax5 Expression Levels To evaluate PC differentiation in vitro at the transcription factor level, we next assessed the expression of IRF4 and Pax5. WebFeb 1, 2024 · ALK + large B-cell lymphomas typically express EMA, CD138, and IRF4/MUM1 but are negative for CD30 (in contrast with anaplastic large cell lymphoma cases) and notably negative to weakly positive for B-cell markers CD20, CD79a, and PAX5, as well as CD45. Finally, plasmablastic morphology in a large B-cell lymphoma should prompt …
Irf4 b cell
Did you know?
WebInterferon regulatory factor 4 (IRF4) rearrangement is commonly detected in patients with a range of lymphoproliferative malignancies, including myelomas, large B cell lymphomas and low-grade B cell neoplasms. However, IRF4 rearrangement is generally a relatively rare finding in these latter two cancer types. WebDec 10, 2024 · IRF4 is implicated in B cell malignancies, acting both as tumor suppressor and as tumor oncogene in different types of precursors and mature B cell neoplasia. Here, we summarize the complexity of IRF4 functions related to different DNA-binding affinity, multiple IRF4-specific target DNA motif, and interactions with transcriptional partners.
WebNov 22, 2024 · IRF4 is also required in B cells for germinal center formation and plasma cell differentiation ( 14 – 16 ). Because of IRF4’s unique role in mature B cells, we hypothesized that it may also have some functions earlier in B cell development that cannot be compensated for by IRF8. WebJan 22, 2024 · However, the previous study mainly utilized Irf4/Irf8 double deficient pre-B cells and it is unclear how the absence of Irf4 influences the obtained results 27. Since we identified Irf4 as ...
WebJP7239597B2 JP2024545734A JP2024545734A JP7239597B2 JP 7239597 B2 JP7239597 B2 JP 7239597B2 JP 2024545734 A JP2024545734 A JP 2024545734A JP 2024545734 A JP2024545734 ... WebB cells require IRF4 to mediate chronic transplant rejection. IRF4 ablation in B cells abrogates allogeneic B cell responses and may also inhibit the ability of B cells to prime …
WebJan 1, 2015 · Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL). The interferon regulatory factor 4 (IRF4) is known to be highly expressed in both ALK + and ALK − ALCLs. However, the role of IRF4 in the …
WebOct 6, 2024 · Sustained IRF4 expression is sufficient to directly repress BCL-6 expression and promote plasma cell differentiation, which may reflect the dose-dependent function … computer basic informationWebApr 14, 2024 · T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as a bottle neck in the field of cancer immunotherapy have undoubtedly provoked attention. One of the main drivers of T cell exhaustion is prolonged antigen presentation, a prerequisite … echo wild game rangers campWebAug 10, 2024 · We find that B-cell differentiation in vivo requires a minimum of eight cell divisions in the absence of cell extrinsic signals. In addition, we define a path to ASC that reveal an early... echo wig reviewWebIRF4. Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, [5] [6] [7] located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B ... echo williamWebNov 22, 2024 · IRF4 is also required in B cells for germinal center formation and plasma cell differentiation ( 14 – 16 ). Because of IRF4’s unique role in mature B cells, we … computer basic question answerWebIRF4 is a gene located on chromosome 6 that encodes for the IRF4 protein belonging to the IRF family of transcription factors. Large B-cell lymphoma with IRF4 rearrangement … echo will not connect to internetWebInterferon regulatory factor 4 (IRF4) rearrangement is a common cytogenetic anomaly reported in various neoplastic lymphoproliferative disorders.IRF4 is a gene located on chromosome 6 that encodes for the IRF4 protein belonging to the IRF family of transcription factors. Large B-cell lymphoma with IRF4 rearrangement constitutes a novel provisional … echo willow